Harnessing SeN to develop novel fluorescent probes for visualizing the variation of endogenous hypobromous acid (HOBr) during the administration of an immunotherapeutic agent

Chem Commun (Camb). 2021 Nov 25;57(94):12679-12682. doi: 10.1039/d1cc04832e.

Abstract

By means of the formation of SeN, the ABT-Se and NDI-Se were developed to detect and visualize endogenous hypobromous acid (HOBr) in live cells. Specifically, the upregulation of HOBr was monitored by NDI-Se during the administration of an immunotherapeutic agent.

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Bromates / administration & dosage
  • Bromates / chemistry*
  • Cell Proliferation / drug effects
  • Cysteine / administration & dosage
  • Cysteine / chemistry
  • Cysteine / pharmacology*
  • Female
  • Fluorescent Dyes / administration & dosage
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Immunotherapy*
  • Injections, Intraperitoneal
  • Mice
  • Molecular Structure
  • Nitrogen / administration & dosage
  • Nitrogen / chemistry
  • Optical Imaging
  • Selenium / administration & dosage
  • Selenium / chemistry
  • Uterine Cervical Neoplasms / drug therapy*
  • Uterine Cervical Neoplasms / pathology

Substances

  • Antineoplastic Agents
  • Bromates
  • Fluorescent Dyes
  • hypobromous acid
  • Selenium
  • Cysteine
  • Nitrogen