A variant t(X;15)(p11;q22) translocation in acute promyelocytic leukemia

Cancer Genet Cytogenet. 1987 Nov;29(1):65-74. doi: 10.1016/0165-4608(87)90031-8.

Abstract

Nonrandom reciprocal translocations involving chromosomes #15 and #17 are characteristic anomalies in a great majority of cases of acute promyelocytic leukemia (APL). Other complex translocations in APL that invariably involve chromosome #17 also have been described. We describe a patient with clinical and morphologic characteristics of APL but with a previously undescribed acquired karyotype, t(X;15)(p11;q22). This is the first translocation in APL described in which chromosome #17 is not involved. Although a comparative structure/function analysis of potentially relevant genes to the translocation breakpoints in both t(X;15) and t(15;17) APL showed no major alterations, the enhanced expression of the c-Ki-ras oncogene observed in t(X;15) APL supports the concept of heterogeneity in APL at the cytogenetic and molecular levels.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Bone Marrow / ultrastructure
  • Chromosome Banding
  • Chromosomes, Human, Pair 15*
  • Female
  • Genetic Markers
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / genetics*
  • Translocation, Genetic*
  • X Chromosome*

Substances

  • Genetic Markers