Variants of concern responsible for SARS-CoV-2 vaccine breakthrough infections from India

Urvashi B Singh; Mercy Rophina; Rama Chaudhry; Vigneshwar Senthivel; Kiran Bala; Rahul C Bhoyar; Bani Jolly; Nayer Jamshed; Mohamed Imran; Ritu Gupta; Praveen Aggarwal; Mohit K Divakar; Subrata Sinha; V R Arvinden; Anjali Bajaj; Afra Shamnath; Abhinav Jain; COVID CBNAAT CORE GROUP; Vinod Scaria; Sridhar Sivasubbu; Randeep Guleria

doi:10.1002/jmv.27461

Variants of concern responsible for SARS-CoV-2 vaccine breakthrough infections from India

J Med Virol. 2022 Apr;94(4):1696-1700. doi: 10.1002/jmv.27461. Epub 2021 Nov 25.

Authors

Urvashi B Singh¹, Mercy Rophina^{2

3}, Rama Chaudhry¹, Vigneshwar Senthivel^{2

3}, Kiran Bala¹, Rahul C Bhoyar², Bani Jolly^{2

3}, Nayer Jamshed⁴, Mohamed Imran^{2

3}, Ritu Gupta⁵, Praveen Aggarwal⁴, Mohit K Divakar^{2

3}, Subrata Sinha⁶, V R Arvinden^{2

3}, Anjali Bajaj^{2

3}, Afra Shamnath², Abhinav Jain^{2

3}; COVID CBNAAT CORE GROUP; Vinod Scaria^{2

3}, Sridhar Sivasubbu^{2

3}, Randeep Guleria⁷

Affiliations

¹ Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
² CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India.
³ Academy for Scientific and Innovative Research, Human Resource Development Centre Campus, Ghaziabad, India.
⁴ Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
⁵ Department of Laboratory Oncology, All India Institute of Medical Sciences, New Delhi, India.
⁶ Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
⁷ Department of Pulmonary Critical Care & Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India.

Abstract

Emerging reports of SARS-CoV-2 breakthrough infections entail methodical genomic surveillance for determining the efficacy of vaccines. This study elaborates genomic analysis of isolates from breakthrough infections following vaccination with AZD1222/Covishield and BBV152/Covaxin. Variants of concern B.1.617.2 and B.1.1.7 responsible for cases surge in April-May 2021 in Delhi, were the predominant lineages among breakthrough infections.

Keywords: COVID-19; SARS-CoV-2; genomic analysis; vaccine breakthrough infections; variants of concern.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
COVID-19 / epidemiology
COVID-19 / prevention & control
COVID-19 / virology*
COVID-19 Vaccines
ChAdOx1 nCoV-19 / administration & dosage
Female
Genome, Viral / genetics
Genomics
Humans
India / epidemiology
Male
Middle Aged
Phylogeny
SARS-CoV-2 / genetics*
SARS-CoV-2 / immunology
SARS-CoV-2 / isolation & purification
Vaccination
Vaccines, Inactivated / administration & dosage
Young Adult

Substances

COVID-19 Vaccines
Vaccines, Inactivated
ChAdOx1 nCoV-19

Supplementary concepts

COVID-19 breakthrough infections
SARS-CoV-2 variants

Grants and funding

Council of Scientific and Industrial Research (CSIR India) through grants CODEST and MLP2005