Abstract
Elucidation of the pharmacodynamic mechanisms of drugs capable of potentiating the effects of non-steroidal anti-inflammatory drugs is an important task. In this in vitro study, the ability of Traumeel S to influence the innate and acquired immunity was evaluated. Traumeel S was found to reduce activities of NADPH oxidase and neutrophil extracellular traps, as well as to evoke anti-inflammatory activity of lymphocyte subpopulations.
Keywords:
Traumeel S; inflammation; lymphocytes; neutrophil extracellular traps; nonsteroidal anti-inflammatory drugs.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.
MeSH terms
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Adaptive Immunity / drug effects
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Extracellular Traps / immunology*
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HLA-DR Antigens / immunology
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Humans
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Immunity, Innate / drug effects
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Inflammation / drug therapy
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Inflammation / pathology
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Leukocytosis / immunology
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Lymphocyte Subsets / immunology
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Minerals / pharmacology*
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NADPH Oxidases / metabolism*
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Neutrophils / immunology
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Plant Extracts / pharmacology*
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T-Lymphocytes / immunology
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fas Receptor / analysis
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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FAS protein, human
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HLA-DR Antigens
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Minerals
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Plant Extracts
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Traumeel S
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fas Receptor
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NADPH Oxidases