Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Dhiraj Yadav; David C Whitcomb; Gong Tang; Adam Slivka; Melena Bellin; North American Pancreatitis Studies Consortium

doi:10.1016/j.cgh.2021.11.011

Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Clin Gastroenterol Hepatol. 2023 Jan;21(1):226-228.e1. doi: 10.1016/j.cgh.2021.11.011. Epub 2021 Nov 16.

Authors

Dhiraj Yadav¹, David C Whitcomb², Gong Tang³, Adam Slivka⁴, Melena Bellin⁵; North American Pancreatitis Studies Consortium

Collaborators

North American Pancreatitis Studies Consortium:
Samer AlKaade, Stephen T Amann, Michelle A Anderson, Peter Banks, Darwin Conwell, Randall E Brand, Gregory A Cote, Joseph Romagnuolo, Christopher E Forsmark, Timothy Gardner, Andres Gelrud, Nalini Guda, Michele Lewis, Thiruvengadam Muniraj, Bimaljit S Sandhu, Stuart Sherman, Vikesh Singh, C Mel Wilcox

Affiliations

¹ Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: [email protected].
² Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Department of Cell Biology & Physiology, Department of Human Genetics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
³ Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
⁴ Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
⁵ Division of Endocrinology and Metabolism, Department of Pediatrics, University of Minnesota Medical Center, Minneapolis, Minnesota.

PMID: 34793964
DOI: 10.1016/j.cgh.2021.11.011

Abstract

Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation.¹.

Trial registration: ClinicalTrials.gov NCT01545167.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
Autoimmunity
Diabetes Mellitus*
Humans
Insulin
Pancreatitis, Chronic* / complications
Pilot Projects

Substances

Insulin

Associated data

ClinicalTrials.gov/NCT01545167