Abstract
Thienamycin derivatives (4) having a cyclic amidine moiety at the C-2 position were prepared. The susceptibility to renal dehydropeptidase-1 and the antimicrobial activity of these compounds were determined. Their structure-activity relationships are also discussed.
MeSH terms
-
Chemical Phenomena
-
Chemistry, Physical
-
Chromatography, High Pressure Liquid
-
Cysteamine*
-
Dipeptidases / metabolism
-
Gram-Negative Bacteria / drug effects
-
Gram-Positive Bacteria / drug effects
-
Imipenem
-
Microbial Sensitivity Tests
-
Structure-Activity Relationship
-
Thienamycins* / pharmacology
Substances
-
Thienamycins
-
Cysteamine
-
Imipenem
-
Dipeptidases
-
dipeptidase
-
thienamycin