Rapid Eye Movement Sleep Behavior Disorder: Abnormal Cardiac Image and Progressive Abnormal Metabolic Brain Pattern

Background: Isolated rapid eye movement sleep behavior disorder (iRBD) is prodromal for α-synucleinopathies.

Objective: The aim of this study was to determine whether pathological cardiac [¹²³ I]meta-iodobenzylguanidine scintigraphy ([¹²³ I]MIBG) is associated with progression of [¹⁸ F]fluorodeoxyglucose-positron emission tomography-based Parkinson's disease (PD)-related brain pattern (PDRP) expression in iRBD.

Methods: Seventeen subjects with iRBD underwent [¹⁸ F]fluorodeoxyglucose-positron emission tomography brain imaging twice ~3.6 years apart. In addition, [¹²³ I]MIBG and [¹²³ I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography ([¹²³ I]FP-CIT-SPECT) at baseline were performed. Olfactory, cognitive, and motor functions were tested annually.

Results: Twelve of 17 subjects had pathological [¹²³ I]MIBG. At baseline, 6 of 12 of these expressed the PDRP (suprathreshold PDRP z score). At follow-up, 12 of 17 subjects had suprathreshold PDRP z scores, associated with pathological [¹²³ I]MIBG in 92% and with pathological [¹²³ I]FP-CIT-SPECT in 75%. Subjects with pathological [¹²³ I]MIBG had higher PDRP z score change per year (P = 0.027). Three subjects phenoconverted to PD; all had pathological [¹²³ I]MIBG and [¹²³ I]FP-CIT-SPECT, suprathreshold baseline PDRP z scores, and hyposmia.

Conclusions: Pathological [¹²³ I]MIBG was associated with progressive and suprathreshold PDRP z scores at follow-up. Abnormal [¹²³ I]MIBG likely identifies iRBD as prodromal PD earlier than pathological [¹²³ I]FP-CIT-SPECT. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.