Comparison between various biosensor methods for human T-lymphotropic virus-1 (HTLV-1) detection

Mol Biol Rep. 2022 Feb;49(2):1513-1517. doi: 10.1007/s11033-021-06959-w. Epub 2021 Nov 19.

Abstract

Due to the drawback of traditional and current diagnostic methods including serological and molecular assays, the development of the rapid and free-PCR techniques can be an alternative technique for the human T-cell lymphotropic virus (HTLV-1) DNA detection sequences. On the other hand, early detection of HTLV-1 prevents two dangerous diseases including Adult T-cell leukemia/lymphoma and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis. The biosensor-based methods are sensitive techniques that can provide new opportunities to detect infectious diseases, particularly in the early stage. This study provides a comparative view among recently designed biosensors for the detection of HTLV-1.

Keywords: Biosensor; Biosensor-based method; HTLV-1; Traditional methods.

Publication types

  • Review

MeSH terms

  • Base Sequence / genetics
  • Biosensing Techniques / methods*
  • HTLV-I Infections / diagnosis*
  • HTLV-I Infections / genetics
  • Human T-lymphotropic virus 1 / genetics*
  • Human T-lymphotropic virus 1 / pathogenicity
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / genetics
  • Leukemia-Lymphoma, Adult T-Cell / pathology
  • Leukemia-Lymphoma, Adult T-Cell / virology
  • Paraparesis, Tropical Spastic / virology
  • Polymerase Chain Reaction / methods