Immunologically Effective Biomaterials

ACS Appl Mater Interfaces. 2021 Dec 8;13(48):56719-56724. doi: 10.1021/acsami.1c14781. Epub 2021 Nov 19.

Abstract

Immunoregulation represents a booming field of biomaterial design. The unique physical and chemical properties of biomaterials offer tremendous opportunities for development. Each of their parameters exerts immunogenic effects at the immune system, cellular, and molecular levels. Herein, the perspective summarizes the interaction of biomaterials with immune cells and the underlying mechanisms to control immunoregulation in a top-down manner, providing solid inspiration for biomedical applications of immunologically effective biomaterials.

Keywords: biomaterial; immune cell; immunostimulation; immunosuppression; intrinsic immunoregulation.

Publication types

  • Review

MeSH terms

  • Antigen-Presenting Cells / chemistry
  • Antigen-Presenting Cells / immunology*
  • Biomimetic Materials / chemical synthesis
  • Biomimetic Materials / chemistry*
  • Homeostasis / immunology
  • Materials Testing