Naltrexone decreases self-injurious behavior

B H Herman; M K Hammock; A Arthur-Smith; J Egan; I Chatoor; A Werner; N Zelnik

doi:10.1002/ana.410220419

Naltrexone decreases self-injurious behavior

Ann Neurol. 1987 Oct;22(4):550-2. doi: 10.1002/ana.410220419.

Authors

B H Herman¹, M K Hammock, A Arthur-Smith, J Egan, I Chatoor, A Werner, N Zelnik

Affiliation

¹ Brain Research Center, Children's Hospital National Medical Center, Washington, DC 20010.

PMID: 3481242
DOI: 10.1002/ana.410220419

Abstract

The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self-injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose-dependent decreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides in SIB.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Dose-Response Relationship, Drug
Humans
Naltrexone / therapeutic use*
Self Mutilation / drug therapy*
Self Mutilation / etiology
Tourette Syndrome / complications
Tourette Syndrome / drug therapy

Substances

Naltrexone