TREX1-dependent DNA damage links nuclear rupture to tumor cell invasion

Edgar R Gomes; Sérgio F de Almeida

doi:10.1016/j.devcel.2021.11.003

TREX1-dependent DNA damage links nuclear rupture to tumor cell invasion

Dev Cell. 2021 Nov 22;56(22):3040-3041. doi: 10.1016/j.devcel.2021.11.003.

Authors

Edgar R Gomes¹, Sérgio F de Almeida²

Affiliations

¹ Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. Electronic address: [email protected].
² Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. Electronic address: [email protected].

PMID: 34813765
DOI: 10.1016/j.devcel.2021.11.003

Abstract

Loss of nuclear integrity correlates with increased DNA damage in different tissues. In a recent issue of Cell, Nader et al. reveal that nuclear envelope ruptures in dense tissue microenvironments cause TREX1-dependent DNA damage and promote the transition from in situ to invasive carcinomas.

Publication types

Comment

MeSH terms

Cell Nucleus*
DNA Damage* / genetics
Nuclear Envelope
Phosphoproteins / genetics

Substances

Phosphoproteins