Objective: To explore the modification effect of physical activity on the genetic effects of type 2 diabetes mellitus (T2DM). Methods: The univariate moderation model was fitted to calculate the modifying effect of physical activity on the genetic effects of T2DM based on the data of 12 107 pairs of same gender twins aged 30 years and older enrolled by the Chinese National Twin Registry in 11 provinces/cities in China. Results: After adjusting for age and gender, the heritability of T2DM was 0.56 (0.31-0.84). Qualified physical activity could attenuate the genetic effects of T2DM. The heritability of T2DM in twin pairs with qualified physical activity was 0.46 (0.06-0.88), which was lower than that in twin pairs without qualified physical activity during the same model [0.68(0.36-0.94)]. Conclusion: T2DM is a moderate genetic disease, physical activity can modify the genetic effects of T2DM.
目的： 探究体力活动对2型糖尿病遗传效应的修饰作用。 方法： 利用中国双生子登记系统在11省/市募集的12 107对≥30岁同性别双生子，拟合单变量交互作用模型计算体力活动对2型糖尿病遗传效应的修饰作用。 结果： 调整年龄、性别后，2型糖尿病的遗传度为0.56（0.31~0.84）。体力活动达标可降低2型糖尿病的遗传效应。体力活动达标双生子2型糖尿病的遗传度为0.46（0.06~0.88），低于相同模型中体力活动未达标双生子2型糖尿病的遗传度［0.68（0.36~0.94）］。 结论： 2型糖尿病属于中度遗传疾病，体力活动可修饰2型糖尿病的遗传效应。.