Selective CDK9 degradation using a proteolysis-targeting chimera (PROTAC) strategy

Future Med Chem. 2022 Jan;14(3):131-134. doi: 10.4155/fmc-2021-0220. Epub 2021 Nov 24.
No abstract available

Keywords: CDK9; PROTAC; cancer; degrader.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cyclin-Dependent Kinase 9 / antagonists & inhibitors*
  • Cyclin-Dependent Kinase 9 / metabolism
  • Flavonoids / chemistry
  • Flavonoids / pharmacology*
  • Humans
  • Protein Kinase Inhibitors / chemistry
  • Protein Kinase Inhibitors / pharmacology*
  • Proteolysis / drug effects
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology*
  • Thiazoles / chemistry
  • Thiazoles / pharmacology*
  • Triazines / chemistry
  • Triazines / pharmacology*

Substances

  • Flavonoids
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Thiazoles
  • Triazines
  • CDK9 protein, human
  • Cyclin-Dependent Kinase 9