Emery-Dreifuss muscular dystrophy with dilated cardiomyopathy preceding skeletal muscle symptoms

Cardiol Young. 2022 Jul;32(7):1175-1177. doi: 10.1017/S1047951121004674. Epub 2021 Nov 25.

Abstract

Emery-Dreifuss muscular dystrophy is a slowly progressive skeletal muscle and joint disorder associated with cardiac complications. Dilated cardiomyopathy was the initial manifestation of Emery-Dreifuss muscular dystrophy in an 8-year-old girl. Despite normal muscle and myocardial biopsies, genetic testing revealed LMNA mutations. As Emery-Dreifuss muscular dystrophy is associated with minimal skeletal muscle weakness, cardiac complications can facilitate its diagnosis.

Keywords: Dilated cardiomyopathy; Emery-Dreifuss muscular dystrophy; LMNA.

Publication types

  • Case Reports

MeSH terms

  • Cardiomyopathy, Dilated* / complications
  • Cardiomyopathy, Dilated* / etiology
  • Child
  • Female
  • Heart
  • Humans
  • Muscle, Skeletal / pathology
  • Muscular Dystrophy, Emery-Dreifuss* / complications
  • Muscular Dystrophy, Emery-Dreifuss* / diagnosis
  • Muscular Dystrophy, Emery-Dreifuss* / genetics
  • Mutation