AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection

Eur J Immunol. 2022 Feb;52(2):352-355. doi: 10.1002/eji.202149574. Epub 2021 Dec 4.

Abstract

A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.

Keywords: CD4; COVID-19; HIV; convalescent plasma; immunocompromised; monoclonal.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / blood
  • Acquired Immunodeficiency Syndrome / immunology*
  • Adult
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism
  • COVID-19 / blood
  • COVID-19 / immunology*
  • Female
  • Humans
  • SARS-CoV-2 / immunology*
  • SARS-CoV-2 / metabolism