Peripheral venous catheter colonization after skin disinfection with 0.5% aqueous sodium hypochlorite, preceded or not by one application of 70% ethanol (DACLEAN): a single-centre, randomized, open-label, pilot study

J Hosp Infect. 2022 Feb:120:123-126. doi: 10.1016/j.jhin.2021.11.012. Epub 2021 Nov 23.

Abstract

Few data are available on the efficacy of 0.5% aqueous sodium hypochlorite (SH) for skin disinfection before peripheral catheter insertion. A total of 239 patients were randomly assigned to either one application of SH alone or one application of SH preceded by one application of 70% ethanol (ET-SH). Catheter colonization, defined as a catheter tip culture growing >1000 cfu of a micro-organism per millilitre, occurred in 29 patients (33% of 89 colonizations per 1000 catheter-days) in the SH group and in 31 patients (33% of 126 colonizations per 1000 catheter-days) in the ET-SH group.

Keywords: Antiseptic; Infection; Prevention; Skin disinfection; Vascular catheter.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Anti-Infective Agents, Local*
  • Catheterization, Central Venous*
  • Catheters
  • Disinfection
  • Ethanol / pharmacology
  • Humans
  • Pilot Projects
  • Skin
  • Sodium Hypochlorite / pharmacology

Substances

  • Anti-Infective Agents, Local
  • Ethanol
  • Sodium Hypochlorite