Systemic sclerosis is a connective tissue disease with cutaneous involvement. Clinical manifestations result from the balance of inflammations/autoimmunity process and fibrogenesis. Patients suffer from skin ulcers, non-ulcerative lesions including digital pitting scars, telangiectasias, subungual hyperkeratosis, abrasions, fissures, and subcutaneous calcinosis. A review about the pathophysiology of the disease, the physical examination of the patients, the instrumental assessment, and possible treatments is performed.
Keywords: Autologous fat grafting; DU, digital ulcer; Digital ulcers; MHISS, Mouth Handicap in Systemic Sclerosis scale; ROM, Range of Motion; RP, Raynaud's phenomenon; SSc, Systemic sclerosis; SU, skin ulcer; Scleroderma; Skin fibrosis; Systemic sclerosis.
© 2021 The Authors.