Perfect adaptation of CD8⁺ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation

Sci Signal. 2021 Jan 19;14(666):eaay9363. doi: 10.1126/scisignal.aay9363. Epub 2021 Jul 15.

Authors

Nicola Trendel¹, Philipp Kruger¹, Stephanie Gaglione¹, John Nguyen¹, Johannes Pettmann^{1

2}, Eduardo D Sontag³, Omer Dushek¹

Affiliations

¹ Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.
² Radcliffe Department of Medicine, Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX1 3RE Oxford, UK.
³ Electrical and Computer Engineering and Bioengineering, Northeastern University, Boston, MA 02115, USA.

Abstract

Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

CD8-Positive T-Lymphocytes*
Lymphocyte Activation*

Grants and funding