Experience in the diagnosis and treatment of a drug-induced pemphigus

Hua Xi Kou Qiang Yi Xue Za Zhi. 2021 Dec 1;39(6):724-727. doi: 10.7518/hxkq.2021.06.016.
[Article in English, Chinese]

Abstract
in English, Chinese

Drug-induced pemphigus (DIP) is a special type of pemphigus, and its pathogenesis, characteristics of treatment, and prognosis are closely related to the inducing drugs. This article reports the diagnosis and treatment of DIP (pemphigus vulgaris) caused by the administration of rifampin to a patient with tuberculosis. Combined with the literature, we discussed the types, pathogenesis, differential diagnosis, and treatment principles of DIP. We propose that in the oral clinical practice for patients with pemphigus vulgaris, the importance of investigating suspected drugs that induce DIP should be emphasized.

药物诱发天疱疮（DIP）是天疱疮的一种特殊类型，其发病机制及治疗预后特点与其诱发药物密切相关。本文报道1例结核病患者服用利福平导致DIP（寻常型天疱疮）的诊治经过，并结合文献讨论DIP的类型、发病机制、鉴别诊断与治疗原则，建议在口腔临床实践中对诊断为寻常型天疱疮的患者应特别强调排查DIP的可能性。.

Keywords: drug-induced pemphigus; pemphigus vulgaris; rifampin; tuberculosis.

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Pemphigus* / diagnosis
  • Pemphigus* / drug therapy
  • Pharmaceutical Preparations*
  • Prognosis

Substances

  • Pharmaceutical Preparations

Grants and funding

[基金项目] 国家自然科学基金（81670998，81872208）