Objective: To describe the distribution and characteristics of peripheral anterior synechiae (PAS) in patients with primary angle-closure glaucoma (PACG). Methods: Retrospective case study. A total of 285 PACG patients (406 eyes) diagnosed in the Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University from January 2017 to August 2019 were included. They were 102 males and 183 females, with a median age of 67 years old (range, 21 to 95 years old). The PAS range was detected by gonioscopy examination, and the frequency distribution of PAS at 12 clock points was counted by clockwise. The PAS distribution at the middle point of PAS with continuous distribution and ≤6 clock points was assessed. Results: In all cases, PAS of the right eye was concentrated at 11:00 to 4:00 regions [range, 62.0% (129/208) to 78.8% (164/208)]. PAS of the left eye was concentrated at 7:00 to 1:00 regions [range, 50.0% (99/198) to 75.8% (150/198)]. When the PAS range of the atrial angle was ≤6 clock regions, it was mainly at 12:00 to 3:00 [range, 58.3% (74/127) to 67.7% (86/127)] in the right eye and at 10:00 to 12:00 [range, 54.8% (68/124) to 66.1% (82/124)] in the left eye. Among 121 cases (242 eyes) with both eyes involved, the PAS region was at 11:00 to 5:00 [range, 52.1% (63/121) to 79.3% (96/121)] in the right eye and at 8:00 to 1:00 [range, 50.4% (61/121) to 76.9% (93/121)] in the left eye. When the PAS range of the atrial angle was ≤6 clock regions, it was mainly at 12:00 to 4:00 [range, 53.2% (41/77) to 71.4% (55/77)] in the right eye and at 10:00 to 12:00 [range, 50.6% (39/77) to 64.9% (50/77)] in the left eye. In all cases, there were 171 cases of right eyes and 175 cases of left eyes with continuous angle PAS. The central PAS clock position of the right eye was mainly at 11:00 to 3:00 [range, 15.2% (26/171) to 24.0% (41/171)], and that of the left eye was mainly at 8:00 to 12:00 [range, 15.4% (27/175) to 20.6% (36/175)]. Among cases with both eyes involved, there were 98 cases of right eyes and 104 cases of left eyes with continuous angle PAS. The clock distribution of the middle position of the right eye angle PAS was concentrated at 11:00 to 3:00 [range, 17.3% (17/98) to 26.5% (26/98)], and that of the left eye was concentrated at 8:00 to 12:00 [range, 13.5% (14/104) to 20.2% (21/104)]. Conclusions: The PAS of PACG patients is mainly located in the upper and nasal sides, and the closer to the temporal side, the smaller the PAS frequency, showing a gradual downward trend. The PAS distribution of binocular angles is of obvious mirror symmetry. (Chin J Ophthalmol, 2021, 57: 666-671).
目的： 观察原发性闭角型青光眼（PACG）患者房角周边虹膜前粘连（PAS）的分布特征。 方法： 回顾性系列病例研究。纳入2017年1月至2019年8月于温州医科大学附属眼视光医院确诊为PACG的285例（406只眼）患者资料，其中男性102例，女性183例，年龄中位数为67岁（范围21~95岁）。收集房角镜动态下的房角PAS范围，分别按顺时针统计12个钟点段PAS的频数分布，并统计PAS范围≤6个钟点等不同范围的房角PAS分布情况及房角PAS呈连续分布者PAS中间钟点位分布情况。 结果： 在全部病例中，右眼房角PAS集中于11：00至4：00方位5个钟点段［62.0%（129/208）~78.8%（164/208）］；左眼房角PAS集中于7：00至1：00方位6个钟点段［50.0%（99/198）~75.8%（150/198）］。房角PAS范围≤6个钟点者中，右眼房角PAS集中于12：00至3：00方位3个钟点段［58.3%（74/127）~67.7%（86/127）］，左眼集中于10：00至12：00方位2个钟点段［54.8%（68/124）、66.1%（82/124）］。双眼均入选者共121例（242只眼），右眼房角PAS集中于11：00至5：00方位6个钟点段［52.1%（63/121）~79.3%（96/121）］，左眼集中于8：00至1：00方位5个钟点段［50.4%（61/121）~76.9%（93/121）］；其中，PAS范围≤6个钟点者的右眼房角PAS主要分布于12：00至4：00方位4个钟点段［53.2%（41/77）~71.4%（55/77）］，左眼主要分布于10：00至12：00方位2个钟点段［50.6%（39/77）、64.9%（50/77）］。在所有病例中，房角PAS为连续性者右眼171只，左眼175只；右眼PAS中间钟点位主要位于11：00至3：00方位4个钟点段［15.2%（26只眼）~24.0%（41只眼）］，左眼主要位于8：00至12：00方位4个钟点段［15.4%（27只眼）~20.6%（36只眼）］。在双眼均入选者中，房角PAS为连续性者右眼98只，左眼104只；右眼PAS中间钟点位主要位于11：00至3：00方位4个钟点段［17.3%（17只眼）~26.5%（26只眼）］，左眼主要位于8：00至12：00方位4个钟点段［13.5%（14只眼）~20.2%（21只眼）］。 结论： PACG患者双眼房角PAS分布主要位于上方及鼻侧，且越向颞侧靠近其PAS频数越小，呈逐渐下降趋势，双眼房角PAS分布呈明显镜面对称。（中华眼科杂志，2021，57：666-671）.