IFT trains overcome an NPHP module barrier at the transition zone

Kwangjin Park; Michel R Leroux

doi:10.1083/jcb.202112015

IFT trains overcome an NPHP module barrier at the transition zone

J Cell Biol. 2022 Jan 3;221(1):e202112015. doi: 10.1083/jcb.202112015. Epub 2021 Dec 10.

Authors

Kwangjin Park^{1

2}, Michel R Leroux^{3

4}

Affiliations

¹ Terry Fox Laboratory, BC Cancer, Vancouver, British Columbia, Canada.
² Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
³ Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
⁴ Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, British Columbia, Canada.

Abstract

Cilia harbor diffusion barriers for soluble and membrane proteins within their proximal-most transition zone (TZ) region and employ an intraflagellar transport (IFT) system to form dynamic motile and signaling compartments. In this issue, De-Castro and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010178) uncover a long-suspected role for the TZ in gating IFT particles.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Biological Transport
Cilia* / metabolism
Diffusion
Membrane Proteins* / genetics
Membrane Proteins* / metabolism
Signal Transduction

Substances

Membrane Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding