Abstract
The synthesis of two Schiff bases of aryl methyl ketones and ethylenediamine 1c, 1d, symmetric adducts of aryl isothiocyanates with Schiff bases 2d-2m and 2-thioxopyrrolidine-4,5-dione derivatives 4d-4m obtained by condensation of oxalyl chloride with Schiff bases of aroylthioacetic acid anilides and ethylenediamine is described. Some of 13 investigated compounds 4a, 4b, 4d-4l, 5a, 5b of 2-thioxopyrrolidine-4,5-dione type showed sedative and analgesic action.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
5-Hydroxytryptophan / pharmacology
-
Analgesics* / chemical synthesis
-
Analgesics* / toxicity
-
Animals
-
Anticonvulsants
-
Drug Interactions
-
Helplessness, Learned
-
Lethal Dose 50
-
Male
-
Mice
-
Motor Activity / drug effects
-
Pyrrolidines / chemical synthesis
-
Pyrrolidines / pharmacology*
-
Pyrrolidines / toxicity
-
Rats
-
Rats, Inbred Strains
-
Sleep / drug effects
-
Stereotyped Behavior / drug effects
Substances
-
Analgesics
-
Anticonvulsants
-
Pyrrolidines
-
5-Hydroxytryptophan