Characterization of a novel plasmid in Serratia marcescens harbouring blaGES-5 isolated from a nosocomial outbreak in Japan

N Nakanishi; S Komatsu; T Iwamoto; R Nomoto

doi:10.1016/j.jhin.2021.11.022

Characterization of a novel plasmid in Serratia marcescens harbouring bla_GES-5 isolated from a nosocomial outbreak in Japan

J Hosp Infect. 2022 Mar:121:128-131. doi: 10.1016/j.jhin.2021.11.022. Epub 2021 Dec 11.

Authors

N Nakanishi¹, S Komatsu¹, T Iwamoto¹, R Nomoto²

Affiliations

¹ Department of Infectious Diseases, Kobe Institute of Health, Kobe, Hyogo, Japan.
² Department of Infectious Diseases, Kobe Institute of Health, Kobe, Hyogo, Japan. Electronic address: [email protected].

PMID: 34906601
DOI: 10.1016/j.jhin.2021.11.022

Abstract

Serratia marcescens is a nosocomial pathogen with carbapenem resistance, which limits the availability of effective treatment options. In this study, molecular characterization of GES-5 carbapenemase-producing S. marcescens isolated from an outbreak in Japan was undertaken. Comparative genetic analysis revealed that the bla_GES-5-encoding plasmid p2020-O-9 is a unique plasmid contributing to carbapenem resistance. Furthermore, this study highlights the need for surveillance programmes to monitor both novel and commonly occurring carbapenemases in clinical settings.

Keywords: Carbapenemase; Serratia marcescens; Whole-genome sequencing; bla(GES-5).

MeSH terms

Anti-Bacterial Agents / pharmacology
Cross Infection* / epidemiology
Disease Outbreaks
Humans
Japan / epidemiology
Microbial Sensitivity Tests
Plasmids / genetics
Serratia Infections* / epidemiology
Serratia marcescens / genetics
beta-Lactamases / genetics

Substances

Anti-Bacterial Agents
beta-Lactamases