Simulation study using the spots deletion technique in spot scanning proton beam therapy for prostate cancers

The aim of the present study was to investigate the effects on the dose distribution and beam delivery time in spot scanning proton beam therapy (PBT) incorporating the spot deletion technique. A spot scanning plan was created for 30 patients with prostate cancer. The plan was then modified via two processes: Spots with lower weighting depositions were deleted (process A) and spots that were distant from the clinical target volume (CTV) were deleted (process B). The dose distribution to the organs at risk (OAR), the expanded CTV (exCTV), which was defined by a uniform expansion of the CTV by a radius of 5 mm, and the beam delivery time were compared among initial and modified plans. The V_{50 Gy [relative biological effectiveness (RBE)]} to the rectum and bladder, and V_{60 Gy(RBE)} to the urethral bulb, inhomogeneity index (INH) of the exCTV showed a difference (P=1.1x10^-14, P=6.4x10^-14, P=2.7x10^-7, P=3.2x10^-17), although only changes by process B were significant. Modified plan by process B showed the V_{50 Gy(RBE)} to the rectum and bladder decreased by -2.4±1.6 and -2.3±1.4%, and the V_{60 Gy (RBE)} to the urethral bulb decreased by -15.9±19.4%. The INH of the exCTV increased by 0.05±0.03%. On the other hand, modification of the initial plan by process A did not affect the dose of the OAR, exCTV or beam delivery time. In spot scanning PBT, modification of the initial radiotherapy plan by systemic deletion of spots distant from the CTV could result in a dose reduction to the OAR.