Abstract
Thousands of known alkaloids contain a nitrogen (N) heterocycle. While five-, six- and seven-membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and their saturated variants) are common, those with an eight-membered N-heterocycle are comparatively rare. This review discusses the structure and bioactivity of alkaloids that contain an azocine (or saturated azocane) ring, and the array of sources whence they originate.
Keywords:
Alkaloid; Azocane; Azocine; Natural product.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Alkaloids / chemistry
-
Alkaloids / isolation & purification
-
Alkaloids / pharmacology*
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / isolation & purification
-
Anti-Infective Agents / pharmacology*
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / isolation & purification
-
Anti-Inflammatory Agents / pharmacology*
-
Antimalarials / chemistry
-
Antimalarials / isolation & purification
-
Antimalarials / pharmacology*
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Azabicyclo Compounds / chemistry
-
Azabicyclo Compounds / isolation & purification
-
Azabicyclo Compounds / pharmacology
-
Azocines / chemistry
-
Azocines / isolation & purification
-
Azocines / pharmacology
-
Humans
-
Insecticides / chemistry
-
Insecticides / isolation & purification
-
Insecticides / pharmacology*
-
Molecular Structure
Substances
-
Alkaloids
-
Anti-Infective Agents
-
Anti-Inflammatory Agents
-
Antimalarials
-
Antineoplastic Agents, Phytogenic
-
Azabicyclo Compounds
-
Azocines
-
Insecticides