Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo- N-thioylpyrrolinate units

Samet Poyraz; Samet Belveren; Sabriye Aydınoğlu; Mahmut Ulger; Abel de Cózar; Maria de Gracia Retamosa; Jose M Sansano; H Ali Döndaş

doi:10.3762/bjoc.17.192

Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo- N-thioylpyrrolinate units

Beilstein J Org Chem. 2021 Dec 2:17:2812-2821. doi: 10.3762/bjoc.17.192. eCollection 2021.

Authors

Samet Poyraz¹, Samet Belveren¹, Sabriye Aydınoğlu², Mahmut Ulger³, Abel de Cózar^{4

5}, Maria de Gracia Retamosa⁶, Jose M Sansano⁶, H Ali Döndaş^{1

2}

Affiliations

¹ Department of Chemistry, Faculty of Pharmacy, Mersin University, Yenisehir, 33169 Mersin, Turkey.
² Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Çukurova University, Balcalı 01330, Adana, Turkey.
³ Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Mersin University, Yenisehir, 33169 Mersin, Turkey.
⁴ Departamento de Química Orgánica I, Facultad de Química. Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU, Centro de Innovación en Química Avanzada (ORFEO-CINQA) and Donostia International Physics Center (DIPC), P. K. 1072, E-20018 San Sebastián, Spain.
⁵ IKERBASQUE, Basque Foundation of Science, Plaza Euskadi 5, 48009, Bilbao, Spain.
⁶ University of Alicante, Department of Organic Chemistry, Centro de Innovación en Química Avanzada (ORFEO-CINQA) and Instituto de Síntesis Orgánica (ISO), PO Box 99, 03080 Alicante, Spain.

Abstract

A series of novel palladium(II) and nickel(II) complexes of multifunctionalized aroylaminocarbo-N-thioylpyrrolinates were synthesized and characterized by analytical and spectroscopic techniques. The biological properties of the freshly prepared compounds were screened against S. aureus, B. subtilis, A. hydrophila, E. coli, and A. baumannii bacteria and antituberculosis activity against M. tuberculosis H37Rv strains. Also, the antifungal activity was studied against C. albicans, C. tropicalis, and C. glabrata standard strains. A deep conformational survey was monitored using DFT calculations with the aim to explain the importance of the final conformation in the biological experimental results.

Keywords: DFT; antituberculosis; bidentate ligands; nickel; palladium.

Grants and funding

This work is a part of Samet POYRAZ's ongoing Ph.D. thesis granted by Mersin University (Project no. 2019-1-TP3-3463). We gratefully acknowledge financial support from Çukurova University and Mersin University (Project no. 2020-1-AP4-3982). We gratefully acknowledge financial support from the Spanish Ministerio de Ciencia, Innovación y Universidades (projects CTQ2016-81893REDT, and RED2018-102387-T) the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P, CTQ2016-80375-P, CTQ2017-82935-P and PID2019-107268GB-I00), the Generalitat Valenciana (IDIFEDER/2021/013, CIDEGENT/2020/058).