Abstract
The effects of dietary fatty acid supplementation on various disease parameters in the spontaneously autoimmune MRL-mp-lpr/lpr mouse model of systemic lupus erythematosus before onset of disease were investigated. A fat deficient diet was supplemented with the following oils: olive oil, sunflower oil, evening primrose oil (EPO), fish oil, and a fish oil/EPO mixture. The mice receiving a diet enriched with EPO showed an increase in survival, as did those receiving the fish oil/EPO mixture. These results, taken together with those of the other parameters monitored, suggest that EPO may be of benefit in alleviating the murine form of the disease.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Antinuclear / analysis
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DNA / immunology
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Fatty Acids, Essential*
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Fatty Acids, Unsaturated / therapeutic use*
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Female
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Fish Oils / therapeutic use
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Linoleic Acids
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Lupus Erythematosus, Systemic / diet therapy*
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Lupus Erythematosus, Systemic / immunology
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Lupus Erythematosus, Systemic / mortality
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Male
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Mice
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Mice, Inbred Strains
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Oenothera biennis
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Oils / therapeutic use*
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Olive Oil
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Plant Oils / therapeutic use
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Rheumatoid Factor / analysis
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Sunflower Oil
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gamma-Linolenic Acid
Substances
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Antibodies, Antinuclear
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Fatty Acids, Essential
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Fatty Acids, Unsaturated
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Fish Oils
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Linoleic Acids
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Oils
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Olive Oil
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Plant Oils
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Sunflower Oil
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evening primrose oil
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gamma-Linolenic Acid
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DNA
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Rheumatoid Factor