Preceding Head Trauma in Four Cases of Sporadic Cerebral Amyloid Angiopathy - Case Report Series

Janja Pretnar Oblak; Ana Jurečič; Karin Writzl; Senta Frol

doi:10.1016/j.jstrokecerebrovasdis.2021.106260

Preceding Head Trauma in Four Cases of Sporadic Cerebral Amyloid Angiopathy - Case Report Series

J Stroke Cerebrovasc Dis. 2022 Feb;31(2):106260. doi: 10.1016/j.jstrokecerebrovasdis.2021.106260. Epub 2021 Dec 18.

Authors

Janja Pretnar Oblak¹, Ana Jurečič², Karin Writzl³, Senta Frol¹

Affiliations

¹ Department of Vascular Neurology, University Medical Centre Ljubljana, Slovenia; Neurology Department, Faculty of Medicine, University of Ljubljana, Slovenia.
² Neurology Department, Faculty of Medicine, University of Ljubljana, Slovenia.
³ Clinical Institute for Medical Genetics, University Medical Centre Ljubljana, Slovenia.

PMID: 34933275
DOI: 10.1016/j.jstrokecerebrovasdis.2021.106260

Abstract

Background: CAA is a heterogeneous group of diseases caused by Aβ deposition in the vascular walls, often leading to lobar ICH and cognitive impairment. Although CAA is rare in younger patients, it has been associated with specific mutations as well as with other causes.

Case presentation: We present four cases of patients with CAA and recurrent ICH who have a history of severe TBI in childhood.

Conclusion: Our cases as well as review of the literature suggest that a history of TBI in patients with genetic predispositions such as male sex may be associated with CAA in young persons.

Keywords: Case report series; Cerebral amyloid angiopathy; Lobar intracerebral hemorrhage; Sporadic cerebral amyloid angiopathy; Traumatic brain injury in childhood.

Publication types

Case Reports
Review

MeSH terms

Cerebral Amyloid Angiopathy* / diagnosis
Cerebral Amyloid Angiopathy* / genetics
Craniocerebral Trauma* / epidemiology
Genetic Predisposition to Disease
Humans
Male