Bhlhe40: Gatekeeper of the GC

Stephen L Nutt; Julie Tellier

doi:10.1084/jem.20212333

Bhlhe40: Gatekeeper of the GC

J Exp Med. 2022 Feb 7;219(2):e20212333. doi: 10.1084/jem.20212333. Epub 2021 Dec 23.

Authors

Stephen L Nutt^{1

2}, Julie Tellier^{1

2}

Affiliations

¹ Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
² Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

Abstract

The generation of high-affinity antibodies in the germinal center (GC) requires interplay between GC B cells and T follicular helper cells. Rauschmeier et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211406) report that Bhlhe40 restrains GC output through distinct regulatory roles in both arms of the response.

Publication types

Comment

MeSH terms

B-Lymphocytes*
Germinal Center*