[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Tanuj Puri; Michelle L Frost; Gary J Cook; Glen M Blake

doi:10.3390/tomography7040071

[¹⁸F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Tomography. 2021 Dec 1;7(4):843-854. doi: 10.3390/tomography7040071.

Authors

Tanuj Puri¹, Michelle L Frost², Gary J Cook³, Glen M Blake¹

Affiliations

¹ Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
² Institute of Cancer Research Clinical Trials & Statistics Unit (ICR-CTSU), Institute of Cancer Research, Sutton SM2 5NG, UK.
³ Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.

Abstract

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([¹⁸F]NaF) to understand bone physiology. Dynamic [¹⁸F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

Keywords: CT; Hawkins model; PET; [18F] sodium fluoride; [18F]NaF; bone metabolism; clinical significance; computed tomography; dynamic positron emission tomography; kinetic modeling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Fluorine Radioisotopes*
Positron-Emission Tomography / methods
Sodium Fluoride* / pharmacokinetics

Substances

Fluorine Radioisotopes
Sodium Fluoride

Grants and funding

DH_/Department of Health/United Kingdom