Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion

Deniz A Madencioglu; Karina Kruth; Mallory Shin; Nancy Andreasen; Thomas Wassink; Aislinn Williams

doi:10.1016/j.scr.2021.102636

Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion

Stem Cell Res. 2022 Mar:59:102636. doi: 10.1016/j.scr.2021.102636. Epub 2021 Dec 21.

Authors

Deniz A Madencioglu¹, Karina Kruth¹, Mallory Shin², Nancy Andreasen¹, Thomas Wassink¹, Aislinn Williams¹

Affiliations

¹ Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.
² Department of Pathology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.

Abstract

16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency and potential to differentiate into the three germ layers.

Abstract

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