Atg1 kinase activity links PAS dissolution to balanced Atg8 conjugation

Oren Shatz; Milana Fraiberg; Zvulun Elazar

doi:10.1016/j.tcb.2021.12.005

Atg1 kinase activity links PAS dissolution to balanced Atg8 conjugation

Trends Cell Biol. 2022 Mar;32(3):179-181. doi: 10.1016/j.tcb.2021.12.005. Epub 2021 Dec 28.

Authors

Oren Shatz¹, Milana Fraiberg¹, Zvulun Elazar²

Affiliations

¹ Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
² Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: [email protected].

PMID: 34969581
DOI: 10.1016/j.tcb.2021.12.005

Abstract

Atg1 phosphoregulates different steps and factors in autophagy. Schreiber et al. report in Molecular Cell on the cell-free identification of a negative feedback ejection of Atg1 from the pre-autophagosomal structure (PAS), followed by positive feedback recruitment of Atg1 to phagophore-resident Atg8-PE, followed by yet another, negative feedback inhibition of the Atg8 conjugation machinery.

Keywords: Atg1 kinase; Atg8-PE; autophagosome; macroautophagy; pre-autophagosomal structure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autophagy / physiology
Autophagy-Related Protein 8 Family* / metabolism
Autophagy-Related Proteins
Phagosomes
Protein Kinases* / metabolism
Solubility

Substances

Autophagy-Related Protein 8 Family
Autophagy-Related Proteins
Protein Kinases