Novel Finding of Copy Number Gains in GNAS and Loss of 10q in a Child With Malignant Transformation of Neurocutaneous Melanosis Syndrome

JCO Precis Oncol. 2021 Nov:5:33-38. doi: 10.1200/PO.20.00244.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / pathology
  • Child
  • Chromogranins / genetics*
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 10
  • DNA Copy Number Variations*
  • Dexamethasone / therapeutic use
  • GTP-Binding Protein alpha Subunits, Gs / genetics*
  • Humans
  • Laminectomy
  • Magnetic Resonance Imaging
  • Male
  • Melanosis / diagnostic imaging
  • Melanosis / genetics*
  • Melanosis / pathology
  • Melanosis / therapy
  • Neurocutaneous Syndromes / diagnostic imaging
  • Neurocutaneous Syndromes / genetics*
  • Neurocutaneous Syndromes / pathology
  • Neurocutaneous Syndromes / therapy
  • Pyridones / therapeutic use
  • Pyrimidinones / therapeutic use

Substances

  • Chromogranins
  • Pyridones
  • Pyrimidinones
  • trametinib
  • Dexamethasone
  • GNAS protein, human
  • GTP-Binding Protein alpha Subunits, Gs

Supplementary concepts

  • Chromosome 10, monosomy 10q
  • Neurocutaneous melanosis