Abstract
Six derivatives of 2-aminoacetyl-1,2,3,4-tetrahydro-beta-carboline (2a-f) were obtained, which yielded as a result of reduction with LiAlH4 six respective 2-aminoethyl-derivatives (3a-f). Pharmacological studies revealed that compounds 2f, 3e and 3f have sedative properties. None of the compounds possesses neuroleptic, antidepressive, anxiolytic, analgesic or anticonvulsant properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Hydroxytryptophan / pharmacology
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Analgesics / chemical synthesis
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Animals
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Anticonvulsants / chemical synthesis
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Apomorphine / pharmacology
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Body Temperature / drug effects
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Carbolines / chemical synthesis*
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Carbolines / pharmacology
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Carbolines / toxicity
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Chemical Phenomena
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Chemistry
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Male
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Mice
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Motor Activity / drug effects
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Psychotropic Drugs / chemical synthesis*
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Psychotropic Drugs / pharmacology
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Psychotropic Drugs / toxicity
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Pyridines / chemical synthesis*
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Pyridines / pharmacology
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Pyridines / toxicity
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Rats
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Rats, Inbred Strains
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Reserpine / pharmacology
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Stereotyped Behavior / drug effects
Substances
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Analgesics
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Anticonvulsants
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Carbolines
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Psychotropic Drugs
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Pyridines
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Reserpine
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5-Hydroxytryptophan
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Apomorphine