Minimal prevalence of HPV vaccination and common occurrence of high-risk HPV types in pregnant women with HIV: data from a national study in Italy

Marco Floridia; Giulia Masuelli; Beatrice Tassis; Valeria M Savasi; Matilde Sansone; Arsenio Spinillo; Laura Franceschetti; Giovanni Guaraldi; Carmela Pinnetti; Serena Dalzero; Alessandra Meloni; Antonella Vimercati; Giuliana Simonazzi; Enrica Tamburrini; Marina Ravizza; Italian Group on Surveillance of Antiretroviral Treatment in Pregnancy

doi:10.1007/s10096-021-04393-1

Minimal prevalence of HPV vaccination and common occurrence of high-risk HPV types in pregnant women with HIV: data from a national study in Italy

Eur J Clin Microbiol Infect Dis. 2022 Mar;41(3):505-509. doi: 10.1007/s10096-021-04393-1. Epub 2022 Jan 9.

Authors

Marco Floridia¹, Giulia Masuelli², Beatrice Tassis³, Valeria M Savasi⁴, Matilde Sansone⁵, Arsenio Spinillo⁶, Laura Franceschetti⁷, Giovanni Guaraldi⁸, Carmela Pinnetti⁹, Serena Dalzero¹⁰, Alessandra Meloni¹¹, Antonella Vimercati¹², Giuliana Simonazzi¹³, Enrica Tamburrini¹⁴, Marina Ravizza¹⁰; Italian Group on Surveillance of Antiretroviral Treatment in Pregnancy

Affiliations

¹ National Centre for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. [email protected].
² Department of Obstetrics and Neonatology, Città della Salute e della Scienza Hospital, and University of Turin, Turin, Italy.
³ Obstetrics and Gynecology Unit, Fondazione IRCCS Ospedale Maggiore Policlinico di Milano, Milan, Italy.
⁴ Department of Obstetrics and Gynaecology, Luigi Sacco Hospital and University of Milan, Milan, Italy.
⁵ Department of Neurosciences, Reproductive and Dentistry Science, University Federico II, Naples, Italy.
⁶ Department of Obstetrics and Gynaecology, IRCCS S. Matteo, Pavia, Italy.
⁷ Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.
⁸ Department of Medical Specialties, Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy.
⁹ I.N.M.I. Lazzaro Spallanzani, Rome, Italy.
¹⁰ Department of Obstetrics and Gynaecology, DMSD San Paolo Hospital Medical School, University of Milan, Milan, Italy.
¹¹ Department of Surgical Sciences, Division of Gynaecology and Obstetrics, University of Cagliari, Cagliari, Italy.
¹² Department of Biomedical and Human Oncological Science (DIMO), 2nd Unit of Obstetrics and Gynaecology, University of Bari, Bari, Italy.
¹³ Department of Medical and Surgical Sciences, Policlinico Sant'Orsola-Malpighi and University of Bologna, Bologna, Italy.
¹⁴ Department of Infectious Diseases, Catholic University and Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

PMID: 34999975
DOI: 10.1007/s10096-021-04393-1

Abstract

Among 733 pregnant women with HIV followed between 2013 and 2021, only 8 (1.1%) had prior HPV vaccination. One had low-grade squamous intraepithelial lesions [LSIL], and none had HPV type information. Among the 725 non-vaccinated women, 578 (79.7%) had information on cervical cytology. Rate of cytologic abnormalities in this group was 20.6% (0.2% atypical glandular cells of undetermined significance [AGC], 1.7% atypical squamous cells of undetermined significance [ASC-US], 11.1% LSIL, and 7.6% high-grade squamous intraepithelial lesions [HSIL]). Among 56 women with HPV type information, 75.0% carried high risk types, with similar occurrence in women with and without cytologic abnormalities, 30.4% had multiple high-risk types, and 75.9% carried at least one of the types included in the currently recommended 9-valent vaccine.

Keywords: Cervical HPV; Cervical cytology; HIV; HPV types; HPV vaccination; Women.

MeSH terms

Female
HIV Infections* / epidemiology
Humans
Papillomaviridae / genetics
Papillomavirus Infections* / epidemiology
Papillomavirus Infections* / prevention & control
Pregnancy
Pregnant People
Prevalence
Uterine Cervical Neoplasms*
Vaccination