¹²⁹Xe Hyper-CEST/¹⁹F MRI Multimodal Imaging System for Sensitive and Selective Tumor Cells Detection

Heteronuclear MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Here we report a novel method for simultaneous acquisition of dual-nuclei hyper-CEST ¹²⁹Xe and ¹⁹F tumor targeting MRI. ¹²⁹Xe hyper-CEST MRI, ¹⁹F MRI and fluorescent imaging were integrated into PFOB nanoemulsion as a imaging system for sensitive and selective tumor cells detection. As the complement to ¹H MRI, ¹²⁹Xe and ¹⁹F signals can also provide efficient and precise anatomical localization of tumors.