Abstract
A series of fifty-five 2-aryl-ethenyl-4-aryl-thiazole-5-acetic acids (IV-LVIII) were synthesized and evaluated for analgesic and antiinflammatory activities. Most of the synthesized compounds showed a good analgesic activity whereas some exhibited significant antiinflammatory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemical synthesis
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Acetates / pharmacology
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Acetates / toxicity
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Behavior, Animal / drug effects
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Chemical Phenomena
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Chemistry
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Male
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Mice
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Rats
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Rats, Inbred Strains
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Stomach Ulcer / chemically induced
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology
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Thiazoles / toxicity
Substances
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Acetates
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Anti-Inflammatory Agents, Non-Steroidal
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Thiazoles