Abstract
The syntheses of some acetamides (II) and phenylureas (III) derived from 2-amino-5-alkoxyphenyl-1,3,4-oxa(thia)diazoles (I) and some 2-alkoxyphenyl-6-phenyl-1,3,4-oxa(thia)diazole-[3,2-a]-s- triazin-5,7-diones (IV) are described. Pharmacological tests showed antiinflammatory and analgesic activities of bicyclic derivatives. A probable influence of alkoxyphenyl substituents, present in three kinds of structures, was observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / chemical synthesis*
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Acetamides / pharmacology
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Acetamides / toxicity
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Chemical Phenomena
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Chemistry
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Lethal Dose 50
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Male
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Mice
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Oxadiazoles / chemical synthesis*
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Oxadiazoles / pharmacology
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Oxadiazoles / toxicity
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Rats
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Rats, Inbred Strains
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Reaction Time / drug effects
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Spectrophotometry, Infrared
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Stomach Ulcer / chemically induced
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Thiadiazoles / chemical synthesis*
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Thiadiazoles / pharmacology
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Thiadiazoles / toxicity
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Triazines / chemical synthesis*
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Triazines / pharmacology
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Triazines / toxicity
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Urea / analogs & derivatives*
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Urea / pharmacology
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Urea / toxicity
Substances
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Acetamides
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Anti-Inflammatory Agents, Non-Steroidal
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Oxadiazoles
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Thiadiazoles
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Triazines
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Urea