Abstract
S. aureus Cowan-induced proliferation of human T lymphocytes was used as a model for evaluating the activity of most common immunosuppressants (steroids, cyclosporine and azathioprine). Methylprednisolone was found to be the most efficient steroid, followed by hydrocortisone and dexamethasone. Cyclosporine (CsA) was a potent inhibitor acting early after B cell stimulation. Azathioprine was found to have low effect on B cell activation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Azathioprine / pharmacology
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B-Lymphocytes / immunology*
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Cyclosporins / pharmacology
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Dexamethasone / pharmacology
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Humans
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Immunosuppressive Agents / pharmacology*
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Lymphocyte Activation* / drug effects
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Methylprednisolone / pharmacology
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Models, Biological
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Staphylococcal Protein A*
Substances
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Cyclosporins
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Immunosuppressive Agents
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Staphylococcal Protein A
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Dexamethasone
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Azathioprine
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Methylprednisolone