Chimeric antigen receptor (CAR) T cell-related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with poor prognosis and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the combination of several techniques for CAR T-cell follow-up, allows a more precise management of this complication.
Keywords: CAR T cells; hemophagocytic lymphohistiocytosis; macrophage activation syndrome; tisagenlecleucel.
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