Objective: We evaluated the association between plasma levels of mac-2 binding protein (M2BP) with the risk of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI).
Methods: Plasma M2BP levels were compared between 258 patients who experienced ISR at 12-months post-PCI and 258 patients, matched for age and sex, without angiographic evidence of ISR.
Results: The plasma M2BP level was significantly higher in the ISR than in the non-ISR group. On multivariate analysis, adjusted for potential clinical, biochemical, and angiography characteristics, M2BP remained as an independent significant predictor of ISR.
Conclusions: M2BP may be an important predictive biomarker of ISR and may be useful in identifying at-risk patients.
Keywords: in-stent restenosis; inflammation; mac-2 binding protein; migration; proliferation; vascular smooth muscle cells.
© 2022 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.