Stability profiling and degradation products of dihydromyricetin in Dulbecco's modified eagle's medium

Food Chem. 2022 Jun 1:378:132033. doi: 10.1016/j.foodchem.2021.132033. Epub 2022 Jan 4.

Abstract

Dihydromyricetin has shown many bioactivities in cell level. However, dihydromyricetin was found to be highly instable in cell culture medium DMEM. Here, the underlying degradation mechanism was investigated via UPLC-MS/MS analysis. Dihydromyricetin was mainly converted into its dimers and oxidized products. At lower temperature, dihydromyricetin in DMEM showed higher stability. Vitamin C increased the stability of dihydromyricetin in DMEM probably due to its high antioxidant potential.

Keywords: Ampelopsin; DMEM; Dihydromyricetin; Quinones; Stability; Vitamin C.

MeSH terms

  • Animals
  • Chromatography, Liquid
  • Culture Media
  • Eagles*
  • Flavonols
  • Tandem Mass Spectrometry

Substances

  • Culture Media
  • Flavonols
  • dihydromyricetin