Respect versus resect approaches for mitral valve repair: A study-level meta-analysis

Trends Cardiovasc Med. 2023 May;33(4):225-239. doi: 10.1016/j.tcm.2022.01.005. Epub 2022 Jan 18.

Abstract

Mitral valve repair (MVr) restores leaflets coaptation while preserving the patient's own valve. The two main techniques are: (a) chordal replacement ("respect approach"), whereby artificial neochordae are used to resuspend prolapsed segments of the affected leaflet - and (b) leaflet resection ("resect approach"), whereby diseased leaflet segment is resected, and the remaining segments are sutured together. Both techniques of MVr are associated with better long-term results, fewer valve-related complications and lower mortality when compared with mitral valve replacement (MVR). They also restore quality of life and improve survival to rates equivalent to those of the general population. We performed a meta-analysis to pool data of clinical studies that compared outcomes of MVr stratified by the surgical technique. Seventeen studies accounting for 6,046 patients fulfilled our eligibility criteria. The "respect approach" outperformed the "resect approach" with lower permanent pacemaker implantation rates and lower mean gradients. Despite any possible advantages of one technique over the other, which approach is best for each patient must be decided on a case-by-case basis and more long-term follow-up data are warranted.

Keywords: Cardiac Valve Annuloplasty; Cardiac surgical procedures; Cardiovascular surgical procedures; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Heart Valves; Meta-analysis; Mitral Valve; Mitral Valve Annuloplasty; Mitral Valve Insufficiency; Mitral Valve Prolapse; Mitral valve repair.

Publication types

  • Meta-Analysis
  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Heart Valve Prosthesis Implantation* / adverse effects
  • Humans
  • Mitral Valve / diagnostic imaging
  • Mitral Valve / surgery
  • Mitral Valve Insufficiency* / diagnostic imaging
  • Mitral Valve Insufficiency* / surgery
  • Mitral Valve Prolapse* / diagnostic imaging
  • Mitral Valve Prolapse* / surgery
  • Quality of Life
  • Respect
  • Treatment Outcome