Abstract
Statistical methods for detecting the contribution of major genes to quantitative phenotypes have been widely applied in human family studies. Some of these methods are reviewed, and their application to analysis of an animal model for a human disease is described. Analysis of lipoprotein concentrations in pedigreed baboons provides evidence for genetic effects on specific lipoprotein components that have been associated with reduced susceptibility to atherosclerosis in humans.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Arteriosclerosis / genetics*
-
Cholesterol / blood
-
Cholesterol, HDL / blood
-
Cholesterol, HDL / genetics
-
Cholesterol, LDL / blood
-
Cholesterol, LDL / genetics
-
Disease Models, Animal
-
Disease Susceptibility
-
Lipoproteins / genetics*
-
Lipoproteins, VLDL / blood
-
Lipoproteins, VLDL / genetics
-
Papio / blood
-
Papio / genetics*
-
Phenotype
Substances
-
Cholesterol, HDL
-
Cholesterol, LDL
-
Lipoproteins
-
Lipoproteins, VLDL
-
Cholesterol