Epigenetic mechanisms of inner ear development

Vinodh Balendran; K Elaine Ritter; Donna M Martin

doi:10.1016/j.heares.2022.108440

Epigenetic mechanisms of inner ear development

Hear Res. 2022 Dec:426:108440. doi: 10.1016/j.heares.2022.108440. Epub 2022 Jan 13.

Authors

Vinodh Balendran¹, K Elaine Ritter², Donna M Martin³

Affiliations

¹ Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, United States.
² Department of Pediatrics, Medical Center Drive, University of Michigan Medical School, 8220C MSRB III, 1150 W, Ann Arbor, MI 48109-5652, United States.
³ Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI, United States; Department of Pediatrics, Medical Center Drive, University of Michigan Medical School, 8220C MSRB III, 1150 W, Ann Arbor, MI 48109-5652, United States; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address: [email protected].

Abstract

Epigenetic factors are critically important for embryonic and postnatal development. Over the past decade, substantial technological advancements have occurred that now permit the study of epigenetic mechanisms that govern all aspects of inner ear development, from otocyst patterning to maturation and maintenance of hair cell stereocilia. In this review, we highlight how three major classes of epigenetic regulation (DNA methylation, histone modification, and chromatin remodeling) are essential for the development of the inner ear. We highlight open avenues for research and discuss how new tools enable the employment of epigenetic factors in regenerative and therapeutic approaches for hearing and balance disorders.

Keywords: Chromatin remodeling; Cochlea; DNA methylation; Hair cells; Histone modification; Otic placode; Spiral ganglia; Supporting cells; Vestibular system.

Epigenetic mechanisms of inner ear development

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