One hundred fifty-five patients with squamous cell carcinoma of the pyriform sinus were treated with curative intent at the University of Florida between 1962 and 1984. All patients were staged according to the AJCC staging system and had a minimum 2-year follow-up; 84% had at least 5 years of follow-up. The locoregional control rates, the incidence of treatment-related complications, and survival rates are presented for radiotherapy as well as for surgery, with or without adjuvant irradiation.