Abstract
Two Keggin polyoxometalates were used as new copper ligands to counteract the effects of CuII(Amyloid-β) interaction. Their ability to remove CuII from CuII(Amyloid-β), to stop CuII(Amyloid-β) induced formation of reactive oxygen species and to restore apo-like self-assembly of CuII(Amyloid-β) was shown.
MeSH terms
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Alzheimer Disease / drug therapy*
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Alzheimer Disease / metabolism
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Amyloid beta-Peptides / antagonists & inhibitors*
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Amyloid beta-Peptides / metabolism
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Anions / chemistry
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Anions / pharmacology*
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Chelating Agents / chemical synthesis
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Chelating Agents / chemistry
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Chelating Agents / pharmacology*
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Copper / chemistry
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Copper / pharmacology*
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Humans
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Polyelectrolytes / chemistry
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Polyelectrolytes / pharmacology*
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Reactive Oxygen Species / metabolism
Substances
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Amyloid beta-Peptides
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Anions
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Chelating Agents
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Polyelectrolytes
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Reactive Oxygen Species
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polyoxometalate
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Copper