Abstract
The correlation between immune responses and protection from SARS-CoV-2 infections and its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over a 17 months period. Pre-vaccination, in 1,493 participants, we scored 266 infections (17.8%) and 8 possible reinfections (3%). Post-vaccination, we identified 30 infections in 2,029 vaccinated individuals (1.5%). We report that the probability of infection post-vaccination is i) significantly lower compared to natural infection, ii) associated with a significantly shorter median duration of infection than that of first infection and reinfection, iii) anticorrelated with circulating antibody levels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antibodies, Anti-Idiotypic / blood*
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Antibodies, Anti-Idiotypic / immunology
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Antibodies, Viral / blood
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Antibodies, Viral / immunology
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COVID-19 / blood
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COVID-19 / immunology*
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COVID-19 / prevention & control
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COVID-19 / virology
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COVID-19 Vaccines / administration & dosage*
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Female
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Humans
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Immunoglobulin G / blood*
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Immunoglobulin G / immunology
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Male
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Mass Vaccination
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Middle Aged
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SARS-CoV-2 / immunology
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SARS-CoV-2 / pathogenicity
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Time Factors
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Young Adult
Substances
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Antibodies, Anti-Idiotypic
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Antibodies, Viral
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COVID-19 Vaccines
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Immunoglobulin G
Grants and funding
Financial support for our study was provided by Fondazione Europea Guido Venosta, National Instruments Corporation, Ralph Lauren and MFS Investment Management. Additional costs were covered through Institutional funds. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.