NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity

Signal Transduct Target Ther. 2022 Jan 31;7(1):32. doi: 10.1038/s41392-022-00892-5.

Authors

Joana Barros-Martins¹, Reinhold Förster^{1

2

3}, Berislav Bošnjak⁴

Affiliations

¹ Institute of Immunology, Hannover Medical School, 30625, Hannover, Germany.
² Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, 30625, Hannover, Germany.
³ German Centre for Infection Research (DZIF), Partner site Hannover, Hannover, Germany.
⁴ Institute of Immunology, Hannover Medical School, 30625, Hannover, Germany. [email protected].

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

COVID-19*
Down-Regulation
Humans
Integrins
Killer Cells, Natural
SARS-CoV-2
Transforming Growth Factor beta*

Substances

Integrins
Transforming Growth Factor beta

Grants and funding