From the dish to humans: A stem cell recipe for success

Holger A Russ; Ali H Shilleh; Lori Sussel

doi:10.1016/j.cmet.2022.01.002

From the dish to humans: A stem cell recipe for success

Cell Metab. 2022 Feb 1;34(2):193-196. doi: 10.1016/j.cmet.2022.01.002.

Authors

Holger A Russ¹, Ali H Shilleh¹, Lori Sussel²

Affiliations

¹ Barbara Davis Center for Diabetes, Department of Pediatrics, University of Colorado Anschutz Medical Campus, 1775 Aurora Court, Aurora, CO 80045, USA.
² Barbara Davis Center for Diabetes, Department of Pediatrics, University of Colorado Anschutz Medical Campus, 1775 Aurora Court, Aurora, CO 80045, USA. Electronic address: [email protected].

Abstract

Islet transplantation has proven to be an effective treatment for type 1 diabetes (T1D) yet is hampered by the shortage of available tissue. Recently, two reports from a Viacyte multicenter clinical trial demonstrate the feasibility, safety, and potential efficacy of transplanting macro-encapsulated human stem cell-derived pancreatic endoderm cells into patients with T1D, highlighting the promise of a stem cell-based therapeutic approach.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Differentiation
Diabetes Mellitus, Type 1* / therapy
Endoderm
Humans
Islets of Langerhans Transplantation*
Stem Cells

Abstract

Publication types

MeSH terms

Grants and funding